Comparison 1. Low vs Standard BP Target.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Total mortality	11	38688	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.86, 1.05]
1.1.1 Systolic target	7	19013	Risk Ratio (M‐H, Fixed, 95% CI)	0.91 [0.80, 1.04]
1.1.2 Diastolic target	4	19675	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.86, 1.20]
1.2 CV mortality	9	37500	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.76, 1.06]
1.2.1 Systolic target	6	17902	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.65, 1.02]
1.2.2 Diastolic target	3	19598	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.80, 1.29]
1.3 Non‐CV mortality	9	37500	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.88, 1.18]
1.3.1 Systolic target	6	17902	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.85, 1.23]
1.3.2 Diastolic target	3	19598	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.81, 1.27]
1.4 Total serious adverse events	6	18165	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.99, 1.08]
1.4.1 Systolic target	5	17827	Risk Ratio (M‐H, Fixed, 95% CI)	1.03 [0.99, 1.08]
1.4.2 Diastolic target	1	338	Risk Ratio (M‐H, Fixed, 95% CI)	1.39 [0.90, 2.15]
1.5 Myocardial infarction	8	38198	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.73, 0.96]
1.5.1 Systolic target	6	18938	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.73, 1.01]
1.5.2 Diastolic target	2	19260	Risk Ratio (M‐H, Fixed, 95% CI)	0.79 [0.61, 1.02]
1.6 Stroke	7	37087	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.77, 1.01]
1.6.1 Systolic target	5	17827	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.67, 0.94]
1.6.2 Diastolic target	2	19260	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.84, 1.34]
1.7 Congestive heart failure	5	15859	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.60, 0.92]
1.7.1 Systolic target	4	15389	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.59, 0.91]
1.7.2 Diastolic target	1	470	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.40, 2.43]
1.8 End‐stage renal failure	6	14768	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.83, 1.37]
1.8.1 Systolic target	4	14353	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.71, 1.36]
1.8.2 Diastolic target	2	415	Risk Ratio (M‐H, Fixed, 95% CI)	1.23 [0.83, 1.82]
1.9 All other serious adverse events	6	18938	Risk Ratio (M‐H, Fixed, 95% CI)	1.44 [1.32, 1.59]
1.9.1 Systolic target	6	18938	Risk Ratio (M‐H, Fixed, 95% CI)	1.44 [1.32, 1.59]
1.10 Systolic blood pressure achieved	11	38688	Mean Difference (IV, Fixed, 95% CI)	‐7.52 [‐7.76, ‐7.27]
1.10.1 Systolic target	7	19013	Mean Difference (IV, Fixed, 95% CI)	‐12.10 [‐12.45, ‐11.74]
1.10.2 Diastolic target	4	19675	Mean Difference (IV, Fixed, 95% CI)	‐3.29 [‐3.63, ‐2.96]
1.11 Diastolic blood pressure achieved	10	35668	Mean Difference (IV, Fixed, 95% CI)	‐4.28 [‐4.41, ‐4.16]
1.11.1 Systolic target	6	15993	Mean Difference (IV, Fixed, 95% CI)	‐6.61 [‐6.83, ‐6.39]
1.11.2 Diastolic target	4	19675	Mean Difference (IV, Fixed, 95% CI)	‐3.18 [‐3.33, ‐3.03]
1.12 Withdrawals due to adverse events	1	318	Risk Ratio (M‐H, Fixed, 95% CI)	2.00 [0.51, 7.86]
1.12.1 Diastolic target	1	318	Risk Ratio (M‐H, Fixed, 95% CI)	2.00 [0.51, 7.86]
1.13 Number of antihypertensive drugs used per patient	7	18240	Mean Difference (IV, Fixed, 95% CI)	1.00 [0.96, 1.04]
1.13.1 Systolic target	6	17902	Mean Difference (IV, Fixed, 95% CI)	1.00 [0.96, 1.04]
1.13.2 Diastolic target	1	338	Mean Difference (IV, Fixed, 95% CI)	0.85 [0.59, 1.11]