Comparison 1. Alirocumab versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Any cardiovascular disease	10	23868	Odds Ratio (IV, Fixed, 95% CI)	0.87 [0.80, 0.94]
1.2 All‐cause mortality	12	24797	Odds Ratio (IV, Fixed, 95% CI)	0.83 [0.72, 0.96]
1.3 Any myocardial infarction	9	23352	Odds Ratio (IV, Fixed, 95% CI)	0.86 [0.79, 0.94]
1.4 Any stroke	8	22835	Odds Ratio (IV, Fixed, 95% CI)	0.73 [0.58, 0.91]
1.5 Influenza	11	23964	Odds Ratio (IV, Fixed, 95% CI)	1.09 [0.83, 1.42]
1.6 Type 2 diabetes mellitus	6	22306	Odds Ratio (IV, Fixed, 95% CI)	0.96 [0.86, 1.07]
1.7 Any cancer	6	3806	Odds Ratio (IV, Fixed, 95% CI)	0.88 [0.61, 1.26]
1.8 Hypertension	10	24347	Odds Ratio (IV, Fixed, 95% CI)	0.92 [0.72, 1.18]