Comparison 1. Antidepressants vs placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Depression response (acute phase)	4	205	Risk Ratio (M‐H, Random, 95% CI)	1.27 [0.97, 1.66]
1.2 Depression remission (acute phase)	4	205	Risk Ratio (M‐H, Random, 95% CI)	1.54 [0.99, 2.41]
1.3 Severity of depression ‐ overall (acute phase)	4	251	Std. Mean Difference (IV, Random, 95% CI)	‐0.30 [‐0.55, ‐0.05]
1.4 Severity of depression ‐ EPDS (acute phase)	2	122	Mean Difference (IV, Random, 95% CI)	‐3.51 [‐6.24, ‐0.78]
1.5 Severity of depression ‐ HAM‐D (acute phase)	3	216	Mean Difference (IV, Random, 95% CI)	‐2.02 [‐4.46, 0.42]
1.6 Severity of depression ‐ CGI‐S (acute phase)	2	110	Mean Difference (IV, Random, 95% CI)	‐0.69 [‐1.87, 0.48]
1.7 Treatment acceptability ‐ dropouts	4	233	Risk Ratio (M‐H, Random, 95% CI)	1.10 [0.74, 1.64]