Summary of findings 3. Antipsychotics compared to another comparator drug or dose for self‐harm in adults.

Antipsychotics compared to another comparator drug or dose for self‐harm in adults
Patient or population: Self‐harm in adults Intervention: Antipsychotics Comparison: Another comparator drug/dose
Outcomes	Relative effect (95% CI)	Anticipated absolute effects* (95% CI)			Certainty of the evidence (GRADE)	What happens
		Without Antipsychotics	With Antipsychotics	Difference
Repetition of SH by post‐intervention № of participants: 53 (1 RCT)	OR 1.51 (0.50 to 4.58)	Study population			⊕⊕⊝⊝ LOW 1 2	Further research is very likely to have an important impact on our confidence in the estimate of the effect of antipsychotics as compared to another comparator drug or dose on repetition of self‐harm by post‐intervention, and may change the estimate.
		34.6%	44.4% (20.9 to 70.8)	9.8% more (13.7 fewer to 36.2 more)
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio;
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate; the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited; the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate; the true effect is likely to be substantially different from the estimate of effect.

¹ We downgraded this domain as this was a relatively older agent.

² We downgraded this domain by one level as the 95% CI for the pooled effect included the null value.