| Study | Reason for exclusion |
|---|---|
| Akbar 2017 | Not an RCT |
| Bakke 2009 | Not participants of interest |
| Bilgihan 2017 | Not an RCT |
| Bouheraoua 2014 | Not an RCT |
| Buzzonetti 2019 | Not participants of interest |
| Cantemir 2017 | Not an RCT |
| Cassagne 2014 | Preliminary report |
| Eraslan 2017 | Not participants of interest |
| Franch 2015 | Not interventions of interest |
| Godefrooij 2018 | Preliminary report |
| Godefrooij 2019 | Not an RCT |
| Godefrooij 2020 | Not an RCT |
| Henriquez 2017 | Not participants of interest |
| Iqbal 2019 | Not participants of interest |
| IRCT2016112231028N1 | Not the intervention of interest |
| JPRN‐UMIN000009372 | Not an RCT |
| Kopaenko 2018 | Not an RCT |
| Madeira 2019 | Not an RCT |
| Magli 2013 | Not an RCT |
| Mesen 2018 | Not an RCT |
| NCT01868620 | Study was terminated early due to few enrollment |
| NCT03080077 | Not participants of interest |
| Rozema 2013 | Not an RCT |
| Rush 2017 | Not participants of interest |
| Salah 2019 | Not an RCT |
| Serrao 2016 | Preliminary report |
| Spadea 2015 | Not an RCT |
| Spadea 2018 | Not an RCT |
| Touboul 2012 | Not an RCT |
| Vinciguerra 2016 | Not an RCT |
| Vinciguerra 2019 | Not an RCT |
| Yuksel 2015 | Not an RCT |
RCT: randomized controlled trial