5. Results by pharmacological group: diosmine, hidrosmine.
| Variables | Dichotomous | Continuous |
| Oedema | RR 0.63 (0.46 to 0.86) | ‐ |
| Oedema (mm) | ‐ | MD ‐5.98 (‐7.78 to ‐4.18) |
| Ulcer cured | NS | ‐ |
| Trophic disorder | RR 0.87 (0.81 to 0.94) | ‐ |
| Pain | NS | SMD ‐0.23 (‐0.41 to ‐0.05) |
| Cramps | RR 0.83 (0.70 to 0.98) | SMD ‐0.46 (‐0.78 to ‐0.14) |
| Restless legs | NS | ‐ |
| Itching | NS | ‐ |
| Heaviness | NS | SMD ‐0.69 (‐1.02 to ‐0.36) |
| Swelling | RR 0.70 (0.52 to 0.94) | SMD ‐0.92 (‐1.26 to ‐0.58) |
| Paraesthesia | NS | NS |
| Quality of life | ‐ | NS |
| Global assessment by the participant | ‐ | SMD ‐0.81 (‐1.14 to ‐0.47) |
| Adverse events | NS | ‐ |
| Note: No measures of effect are specified when I2 was > 75% for the subgroup | ||
MD: mean difference NS: non‐significant RR: risk ratio SMD: standardized mean difference