| 4.1 Oedema in the lower legs (dichotomous variable) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 4.1.1 Calcium dobesilate |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 4.2 Ankle perimeter circumference (mm) |
3 |
867 |
Mean Difference (IV, Random, 95% CI) |
‐2.34 [‐8.79, 4.11] |
| 4.2.1 Calcium dobesilate |
3 |
867 |
Mean Difference (IV, Random, 95% CI) |
‐2.34 [‐8.79, 4.11] |
| 4.3 Quality of life |
2 |
617 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.60 [‐2.15, 0.95] |
| 4.3.1 Calcium dobesilate at 3 months of treatment |
2 |
617 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.60 [‐2.15, 0.95] |
| 4.4 Pain in the lower legs (dichotomous variable) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 4.4.1 Rutosides |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 4.5 Pain in the lower legs (continuous variable) |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 4.5.1 Calcium dobesilate |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 4.6 Cramps in the lower legs (continuous variable) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.6.1 Calcium dobesilate |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.7 Itching in the lower legs (dichotomous variable) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 4.7.1 Rutosides |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 4.8 Itching in the lower legs (continuous variable) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.8.1 Calcium dobesilate |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.9 Heaviness in the lower legs (dichotomous variable) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 4.9.1 Rutosides |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 4.10 Heaviness in the lower legs (continuous variable) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.10.1 Calcium dobesilate |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.11 Swelling in the lower legs (dichotomous variable) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 4.11.1 Rutosides |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 4.12 Swelling in the lower legs (continuous variable) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.12.1 Calcium dobesilate |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.13 Participant satisfaction (dichotomous variable) |
2 |
476 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.04 [0.81, 1.32] |
| 4.13.1 Calcium dobesilate |
2 |
476 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.04 [0.81, 1.32] |
| 4.14 Participant satisfaction (continuous variable) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.14.1 Calcium dobesilate |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.15 Adverse events |
4 |
1257 |
Risk Ratio (M‐H, Random, 95% CI) |
1.59 [0.97, 2.63] |
| 4.15.1 Calcium dobesilate |
3 |
1026 |
Risk Ratio (M‐H, Random, 95% CI) |
1.53 [0.76, 3.09] |
| 4.15.2 Rutosides |
1 |
231 |
Risk Ratio (M‐H, Random, 95% CI) |
1.83 [1.00, 3.34] |
