Agranulocytosis	also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous leukopenia (lowered white blood cell count), most commonly of neutrophils, and thus causing a neutropenia in the circulating blood
Anatomical Therapeutic Chemical (ATC) Classification System	drug classification system that classifies the active ingredients of drugs according to the organ or system on which they act and their therapeutic, pharmacological, and chemical properties
Capillary hyperpermeability	the capacity of a blood vessel wall to allow for the flow of small molecules (drugs, nutrients, water, ions) or even whole cells (lymphocytes on their way to the site of inflammation) in and out of the vessel
Chronic venous insufficiency (CVI)	a condition in which veins are unable to transport blood unidirectionally toward the heart, usually occurs in the lower limbs
Corona phlebectatica	cutaneous sign of chronic venous insufficiency, characterised by abnormally dilated veins around the ankle
Exacerbations	the process of making a problem, bad situation, or negative feeling worse
Lipodermatosclerosis	hardening of the skin that may cause red/brown pigmentation and is accompanied by wasting of subcutaneous fat
Paraesthesias	abnormal sensations, such as prickling, burning, tingling) in the lower legs
Pathophysiology	the disordered physiological processes associated with disease or injury
Reticular veins	dilated veins that show as a net‐like pattern on the skin
Telangiectasia	condition in which widened venules (tiny blood vessels) cause threadlike red lines or patterns on the skin
Thrombosis	formation of a blood clot, known as a thrombus, within a blood vessel. It prevents blood from flowing normally through the circulatory system
Varicose veins	permanently dilated veins
Vasoprotective drug	medication which acts to alleviate or prevent conditions or diseases which affect the blood vessels