Guilhou 1997.

Study characteristics
Methods	Study design: randomised, multi‐centre, double‐blind, placebo‐controlled Method of randomisation: not stated Exclusions post randomisation: none Losses to follow‐up: 6/107 (6%)
Participants	Country: France Setting: hospital Number: 107 patients Age: 'adults' Gender: 30 M:77 F Inclusion criteria: venous ulcers Exclusion criteria: not stated Randomisation of treatment stratified according to ulcer size: < 10 cm or ≥ 10 cm
Interventions	Treatment: diosmine 450 mg plus hesperidin 50 mg per 12 hours plus compression stockings Control: placebo and standard compression stockings Duration: 60 days Follow‐up: 60 days
Outcomes	Primary Percentage of participants with complete healing at 2 months Secondary Percentage of surface area healed Aspect of ulcer and peri‐ulcerous skin of the reference ulcer Total number of healed ulcers in cases of multiple ulcers Evolution of symptoms of CVI Socioeconomic incidence
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "Randomisation of treatment was stratified according to the size of the ulcers" Comment: no method of randomisation described
Allocation concealment (selection bias)	Unclear risk	Comment: no method of allocation concealment described
Blinding (patients)	Unclear risk	Comment: no information given about methods used for blinding
Blinding (study researchers)	Unclear risk	Comment: no information given about methods used for blinding
Blinding (outcome assessment)	Unclear risk	Comment: no information given about methods used for blinding
Incomplete outcome data	Low risk	Comment: number of participants in each group described. ITT analysis conducted. Information provided about participants who withdrew prematurely from the study, along with reasons for premature withdrawal
Selective reporting	Low risk	Comment: no published protocol identified, and no differences between outcomes reported in the methods section and those reported in the results section
Other bias	Low risk	Comment: none detected