Comparison 6. Corticosteroids versus placebo or no treatment ‐ decade of trial.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
6.1 Perinatal death ‐ decade of trial	14	9833	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.77, 0.93]
6.1.1 Trials conducted in 1970s	5	2520	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.74, 1.06]
6.1.2 Trials conducted in 1980s	1	77	Risk Ratio (M‐H, Fixed, 95% CI)	1.14 [0.59, 2.21]
6.1.3 Trials conducted in 1990s	3	615	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.46, 0.97]
6.1.4 Trials conducted in 2000s	2	414	Risk Ratio (M‐H, Fixed, 95% CI)	0.46 [0.31, 0.70]
6.1.5 Trials conducted in 2010s	3	6207	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.79, 0.99]
6.2 Neonatal death ‐ decade of trial	22	10609	Risk Ratio (M‐H, Fixed, 95% CI)	0.78 [0.70, 0.87]
6.2.1 Trials conducted in 1970s	7	2743	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.67, 1.04]
6.2.2 Trials conducted in 1980s	4	326	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.55, 1.49]
6.2.3 Trials conducted in 1990s	5	788	Risk Ratio (M‐H, Fixed, 95% CI)	0.60 [0.40, 0.90]
6.2.4 Trials conducted in 2000s	2	270	Risk Ratio (M‐H, Fixed, 95% CI)	0.46 [0.31, 0.66]
6.2.5 Trials conducted in 2010s	4	6482	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.72, 0.96]
6.3 Fetal death ‐ decade of trial	14	9833	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.83, 1.22]
6.3.1 Trials conducted in 1970s	5	2520	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.69, 1.32]
6.3.2 Trials conducted in 1980s	1	77	Risk Ratio (M‐H, Fixed, 95% CI)	3.42 [0.37, 31.41]
6.3.3 Trials conducted in 1990s	3	615	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.49, 2.36]
6.3.4 Trials conducted in 2000s	2	414	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.19, 4.50]
6.3.5 Trials conducted in 2010s	3	6207	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.79, 1.30]
6.4 Respiratory distress syndrome ‐ decade of trial	26	11183	Risk Ratio (M‐H, Fixed, 95% CI)	0.71 [0.65, 0.78]
6.4.1 Trials conducted in 1970s	8	2823	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.54, 0.78]
6.4.2 Trials conducted in 1980s	4	326	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.55, 0.88]
6.4.3 Trials conducted in 1990s	5	788	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.65, 0.92]
6.4.4 Trials conducted in 2000s	5	845	Risk Ratio (M‐H, Fixed, 95% CI)	0.40 [0.26, 0.59]
6.4.5 Trials conducted in 2010s	4	6401	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.69, 0.98]
6.5 IVH ‐ decade of trial	12	8475	Risk Ratio (M‐H, Fixed, 95% CI)	0.58 [0.45, 0.75]
6.5.1 Trials conducted in 1970s	1	1218	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.33, 1.12]
6.5.2 Trials conducted in 1980s	3	510	Risk Ratio (M‐H, Fixed, 95% CI)	0.46 [0.26, 0.81]
6.5.3 Trials conducted in 1990s	4	580	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.44, 0.90]
6.5.4 Trials conducted in 2000s	2	270	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.15, 0.73]
6.5.5 Trials conducted in 2010s	2	5897	Risk Ratio (M‐H, Fixed, 95% CI)	2.40 [0.69, 8.31]
6.6 Birthweight ‐ decade of trial	19	9551	Mean Difference (IV, Fixed, 95% CI)	‐14.02 [‐33.79, 5.76]
6.6.1 Trials conducted in 1970s	5	1822	Mean Difference (IV, Fixed, 95% CI)	‐41.39 [‐110.05, 27.26]
6.6.2 Trials conducted in 1980s	3	280	Mean Difference (IV, Fixed, 95% CI)	‐19.60 [‐108.55, 69.35]
6.6.3 Trials conducted in 1990s	4	569	Mean Difference (IV, Fixed, 95% CI)	‐33.13 [‐102.39, 36.13]
6.6.4 Trials conducted in 2000s	3	573	Mean Difference (IV, Fixed, 95% CI)	‐20.77 [‐61.95, 20.41]
6.6.5 Trials conducted in 2010s	4	6307	Mean Difference (IV, Fixed, 95% CI)	‐3.82 [‐30.36, 22.72]
6.7 Chorioamnionitis ‐ decade of trial	15	8374	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.69, 1.08]
6.7.1 Trials conducted in 1970s	2	1237	Risk Ratio (M‐H, Fixed, 95% CI)	0.74 [0.46, 1.17]
6.7.2 Trials conducted in 1980s	3	276	Risk Ratio (M‐H, Fixed, 95% CI)	0.50 [0.25, 1.01]
6.7.3 Trials conducted in 1990s	5	731	Risk Ratio (M‐H, Fixed, 95% CI)	1.27 [0.85, 1.89]
6.7.4 Trials conducted in 2000s	2	257	Risk Ratio (M‐H, Fixed, 95% CI)	2.02 [0.59, 6.95]
6.7.5 Trials conducted in 2010s	3	5873	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.48, 1.11]
6.8 Endometritis ‐ decade of trial	10	6764	Risk Ratio (M‐H, Fixed, 95% CI)	1.14 [0.82, 1.58]
6.8.1 Trials conducted in 1970s	1	101	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.07, 15.86]
6.8.2 Trials conducted in 1980s	1	71	Risk Ratio (M‐H, Fixed, 95% CI)	2.30 [0.88, 6.06]
6.8.3 Trials conducted in 1990s	4	574	Risk Ratio (M‐H, Fixed, 95% CI)	0.87 [0.53, 1.44]
6.8.4 Trials conducted in 2000s	4	6018	Risk Ratio (M‐H, Fixed, 95% CI)	1.23 [0.75, 2.03]