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. 2020 Dec 25;2020(12):CD004454. doi: 10.1002/14651858.CD004454.pub4

Comparison 8. Corticosteroids versus placebo or no treatment ‐ gestational age at trial entry.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
8.1 Perinatal death ‐ gestational age at trial entry 14 9833 Risk Ratio (M‐H, Fixed, 95% CI) 0.84 [0.77, 0.92]
8.1.1 Less than or equal to 35 weeks + 0 days 11 6185 Risk Ratio (M‐H, Fixed, 95% CI) 0.83 [0.76, 0.91]
8.1.2 Greater than or equal to 34 weeks + 0 days 4 3648 Risk Ratio (M‐H, Fixed, 95% CI) 1.70 [0.68, 4.28]
8.2 Neonatal death ‐ gestational age at trial entry 22 10609 Risk Ratio (M‐H, Fixed, 95% CI) 0.78 [0.70, 0.86]
8.2.1 Less than or equal to 35 weeks + 0 days 19 6961 Risk Ratio (M‐H, Fixed, 95% CI) 0.77 [0.69, 0.86]
8.2.2 Greater than or equal to 34 weeks + 0 days 4 3648 Risk Ratio (M‐H, Fixed, 95% CI) 1.51 [0.49, 4.61]
8.3 Fetal death ‐ gestational age at trial entry 14 9833 Risk Ratio (M‐H, Fixed, 95% CI) 1.00 [0.83, 1.20]
8.3.1 Less than or equal to 35 weeks + 0 days 11 6185 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.81, 1.19]
8.3.2 Greater than or equal to 34 weeks + 0 days 4 3648 Risk Ratio (M‐H, Fixed, 95% CI) 1.92 [0.42, 8.82]
8.4 Respiratory distress syndrome ‐ gestational age at trial entry 26 11183 Risk Ratio (M‐H, Fixed, 95% CI) 0.71 [0.65, 0.78]
8.4.1 Less than or equal to 35 weeks + 0 days 20 7041 Risk Ratio (M‐H, Fixed, 95% CI) 0.70 [0.63, 0.78]
8.4.2 Greater than or equal to 34 weeks + 0 days 7 4142 Risk Ratio (M‐H, Fixed, 95% CI) 0.75 [0.60, 0.95]
8.5 IVH ‐ gestational age at trial entry 12 8475 Risk Ratio (M‐H, Fixed, 95% CI) 0.58 [0.45, 0.74]
8.5.1 Less than or equal to 35 weeks + 0 days 11 5412 Risk Ratio (M‐H, Fixed, 95% CI) 0.56 [0.44, 0.72]
8.5.2 Greater than or equal to 34 weeks + 0 days 2 3063 Risk Ratio (M‐H, Fixed, 95% CI) 4.91 [0.24, 102.09]
8.6 Birthweight ‐ gestational age at trial entry 19 9551 Mean Difference (IV, Fixed, 95% CI) ‐13.36 [‐32.99, 6.26]
8.6.1 Less than or equal to 35 weeks + 0 days 13 5412 Mean Difference (IV, Fixed, 95% CI) ‐9.78 [‐40.81, 21.24]
8.6.2 Greater than or equal to 34 weeks + 0 days 7 4139 Mean Difference (IV, Fixed, 95% CI) ‐15.75 [‐41.09, 9.58]
8.7 Chorioamnionitis ‐ gestational age at trial entry 15 8374 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.68, 1.07]
8.7.1 Less than or equal to 35 weeks + 0 days 13 5132 Risk Ratio (M‐H, Fixed, 95% CI) 0.94 [0.73, 1.20]
8.7.2 Greater than or equal to 34 weeks + 0 days 3 3242 Risk Ratio (M‐H, Fixed, 95% CI) 0.58 [0.34, 0.99]