Lopez 1989.

Study characteristics
Methods	Type of study: RCT Method of treatment allocation: not described Stratification: not stated Placebo: no. Sample size calculation: not stated Intention‐to‐treat analyses: not stated however, all those randomised were analysed Losses to follow‐up: nil
Participants	Location: Department of Obstetrics and Gynecology, Faculty of Medicine, National Univeristy of Colombia Eligibility criteria: PROM (confirmed using speculoscopy and ultrasound), no signs of infection, not in labour at time of hospitalisation Gestational age range: 27‐35 weeks' gestation Exclusion criteria: not stated Total recruited: 20 control group, 20 study group 40 women, 40 infants
Interventions	The treatment group received 2 doses of 12 mg betamethasone IM, 12 hours apart. The control group received no treatment.
Outcomes	Neonatal mortality, RDS, Apgar score < 7 at 5 minutes, systemic infection in first 48 hours
Notes	Original article in Spanish, translated into English Study dates: August 1983‐December 1985 Funding: not stated Declarations of interest: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not stated other than quote: "patients were classified randomly into groups"
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding of participants and personnel (performance bias) All outcomes	High risk	Comparison is "no treatment" so blinding not possible
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Blinding of outcome assessors was not described.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses to follow‐up reported
Selective reporting (reporting bias)	Low risk	Study protocol not available, but appears to report on all pre‐specified outcomes
Other bias	Low risk	Nothing to indicate any other sources of bias exist.