Figure 7.

Expression of Cyclin B1 and Skp2 in Ts65Dn mice. Evaluation of the expression of Cyclin B1 (CcnB1) and Skp2 by western blot analysis in the cerebellum of P2 control (n = 6) and Ts65Dn (n = 6) mice. A: Examples of western blots of control (left) and Ts65Dn (right) mice. B: Quantification of the expression of Cyclin B1 and Skp2 normalized to actin levels. Note that Ts65Dn mice have a lower expression of Cyclin B1 and Skp2 with respect to controls. In contrast, Ts65Dn mice have a 1.5 fold higher expression of the triplicated gene App. Values are means ± SEM. *P < 0.05; **P < 0.01 (Student's two tailed t‐test).