Table 1.
Stereological data for the cerebellum of P2 control and Ts65Dn mice.
| Cerebellum (P2) | Volume (mm3) | Thickness (µm) | GCP density (cell/mm3) (1 × 106) | Total GCP number (1 × 106) | Total pyknotic cell number | |
|---|---|---|---|---|---|---|
| EGL | Control | 0.340 ± 0.010 | 21.408 ± 2.569 | 6.407 ± 0.396 | 2.203 ± 0.496 | 321.3 ± 12.5 |
| Ts65Dn | 0.229 ± 0.016** | 15.767 ± 1.865** | 5.510 ± 0.359* | 1.246 ± 0.251* | 1632 ± 98.0** | |
| oEGL | Control | 0.187 ± 0.021 | 13.109 ± 1.336 | 6.596 ± 0.487 | 1.232 ± 0.482 | 139.2 ± 9.84 |
| Ts65Dn | 0.153 ± 0.024* | 10.466 ± 1.004** | 5.658 ± 0.413* | 0.865 ± 0.478* | 994.1 ± 69.4** | |
| iEGL | Control | 0.153 ± 0.019 | 8.299 ± 1.496 | 6.345 ± 0.406 | 0.970 ± 0.321 | 183.1 ± 19.2 |
| Ts65Dn | 0.076 ± 0.011** | 5.509 ± 1.299** | 5.008 ± 0.481* | 0.380 ± 0.125** | 637.7 ± 51.7** | |
| ML | Control | 0.284 ± 0.010 | N/A | N/A | N/A | N/A |
| Ts65Dn | 0.254 ± 0.027 | |||||
| IGL | Control | 0.633 ± 0.027 | N/A | N/A | N/A | N/A |
| Ts65Dn | 0.531 ± 0.022* | |||||
Abbreviations: EGL = external granular layer; oEGL = outer external granular layer; iEGL = inner external granular layer; ML = molecular layer; IGL = inner granular layer; GCP = granular cell precursors; N/A = not available. Measurement of inner granular layer includes the layer of the Purkinje cells. The numbers are mean ± SEM (n = 6 control mice; n = 6 Ts65Dn mice). *P < 0.05; **P < 0.01 (Student's two tailed t‐test).