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Experimental protocol. Starting from the age of 12 months, euploid (n = 3) and Ts65Dn (n = 3) mice were treated with lithium, administered through the food pellets for 1 month. Age‐matched euploid (n = 3) at Ts65Dn (n = 3) animals were used as controls. During the last 3 days animals of all groups received a daily intraperitoneal injection (150 µg/g body weight) of BrdU and were sacrificed 24 h after the last BrdU injection.
