Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 May 20;20(2):367–377. doi: 10.1111/j.1750-3639.2009.00286.x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2009 The Authors; Journal Compilation © 2009 International Society of Neuropathology

PMC Copyright notice

Mitotic epitopes demarcating NFT. Hippocampal sections from a 31‐year‐old case were immunostained with MPM‐2 (panels A, D), H14 (panel B), H5 (panels C, E), cdc2 (panel F) and cyclin B1 (G) and counter‐stained with hematoxylin (all panels, bar = 40 microns). Classic NFT were stained with every antibody (panels A and D for MPM‐2, and panel B for H14, and C and E, H‐5), but cdc2 and cyclin B1 staining of some neurons lacking obvious NFT was more prominent (panels F and G, respectively). The H5 staining shows a shift in distribution of the enzyme from the nucleus (panel C, arrowhead) to the cytoplasm (panel C, arrow, and inset). MPM‐2 (panel D, red) and H5 (panel E, green) colocalize in the same NFT.