Table 4.
The table summarizes the results of repetitive O6‐methylguanine‐methyltransferase methylation‐specific polymerase‐chain reaction (MGMT MSP) testing in four glioblastoma cases. Abbreviations: m = methylated MGMT promoter; u = unmehtylated MGMT promoter.
| Fixation type | RCL2 | Formalin | ||
|---|---|---|---|---|
| MGMT MSP run | 1 | 2 | 1 | 2 |
| N1420‐08 | u | u | u | Invalid |
| N234‐09 | u | u | Invalid | u |
| N1509‐08 | m | m | m | m |
| N392‐09 | m | m | m | m |
In each case, two MGMT MSP analyses were performed from a RCL2‐fixed and paraffin‐embedded (RCLPE) specimen and two analyses were performed from a formalin‐fixed and paraffin‐embedded (FFPE) specimen. MGMT MSP was successful in eight of eight analyses from RCLPE specimens. In contrast, in FFPE specimens MGMT MSP yielded invalid results in two of eight analyses.