Comparison 1. RCT: paroxetine versus doxepin.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 > 50% reduction in depressive symptoms	1	67	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.88, 1.52]
1.2 Mean depression scores	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.2.1 HAMD scores	1	67	Mean Difference (IV, Fixed, 95% CI)	0.65 [‐2.15, 3.45]
1.3 Withdrawals (any reason)	1	67	Risk Ratio (M‐H, Fixed, 95% CI)	0.15 [0.01, 2.74]
1.4 Adverse effects	1		Risk Ratio (M‐H, Fixed, 99% CI)	Subtotals only
1.4.1 Blurred vision	1	67	Risk Ratio (M‐H, Fixed, 99% CI)	0.34 [0.09, 1.32]
1.4.2 Dizziness	1	67	Risk Ratio (M‐H, Fixed, 99% CI)	0.21 [0.03, 1.37]
1.4.3 Dry mouth	1	67	Risk Ratio (M‐H, Fixed, 99% CI)	0.26 [0.06, 1.20]
1.4.4 Sleep disorders	1	67	Risk Ratio (M‐H, Fixed, 99% CI)	0.32 [0.08, 1.20]
1.4.5 Urinary retention	1	67	Risk Ratio (M‐H, Fixed, 99% CI)	0.34 [0.01, 21.99]