| 4.1 Mean depression scores (BDI) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 4.1.1 BDI‐II scores at 8 weeks |
1 |
104 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.50 [‐6.28, 1.28] |
| 4.1.2 BDI‐II scores at 16 weeks |
1 |
117 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.50 [‐4.47, 3.47] |
| 4.2 Remission in depressive symptoms |
1 |
140 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.88 [0.65, 1.17] |
| 4.3 Seizure frequency |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 4.3.1 Generalised tonic‐clonic seizures per month at 8 weeks |
1 |
86 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐0.26, 0.06] |
| 4.3.2 Generalised tonic‐clonic seizures per month at 16 weeks |
1 |
96 |
Mean Difference (IV, Fixed, 95% CI) |
0.00 [‐0.10, 0.10] |
| 4.3.3 Focal seizures with impaired awareness per month at 8 weeks |
1 |
75 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.60 [‐6.52, 1.32] |
| 4.3.4 Focal seizures with impaired awareness per month at 16 weeks |
1 |
73 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.00 [‐7.81, 1.81] |
| 4.4 Seizure recurrence |
1 |
104 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.04 [0.27, 3.94] |
| 4.5 Withdrawals (any reason) |
1 |
140 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.26 [0.64, 2.46] |
| 4.6 Quality of life (QOLIE‐89) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 4.6.1 QOLIE‐89 score at 8 weeks |
1 |
104 |
Mean Difference (IV, Fixed, 95% CI) |
6.10 [‐0.28, 12.48] |
| 4.6.2 QOLIE‐89 score at 16 weeks |
1 |
118 |
Mean Difference (IV, Fixed, 95% CI) |
3.10 [‐3.41, 9.61] |
| 4.7 Adverse events profile |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 4.7.1 Adverse event profile at 8 weeks |
1 |
106 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.70 [‐6.62, 1.22] |
| 4.7.2 Adverse event profile at 16 weeks |
1 |
118 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.10 [‐6.21, 2.01] |
| 4.8 Adverse events |
1 |
|
Risk Ratio (M‐H, Fixed, 99% CI) |
Subtotals only |
| 4.8.1 Anxiety |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
8.51 [0.19, 386.16] |
| 4.8.2 Chest pain |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
0.47 [0.05, 4.21] |
| 4.8.3 Cold |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
0.63 [0.13, 3.13] |
| 4.8.4 Diarrhoea |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
19.85 [0.49, 805.53] |
| 4.8.5 Dizziness |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
1.51 [0.37, 6.14] |
| 4.8.6 Dry mouth |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
3.78 [0.22, 65.10] |
| 4.8.7 Headache |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
1.48 [0.69, 3.19] |
| 4.8.8 Insomnia |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
2.16 [0.73, 6.38] |
| 4.8.9 Memory difficulty |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
0.71 [0.10, 4.82] |
| 4.8.10 Muscle strain or pain |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
1.21 [0.36, 4.12] |
| 4.8.11 Nausea |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
2.60 [0.62, 10.96] |
| 4.8.12 Rash |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
4.72 [0.29, 76.72] |
| 4.8.13 Sexual dysfunction |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
8.51 [0.19, 386.16] |
| 4.8.14 Shakiness |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
12.28 [0.88, 171.59] |
| 4.8.15 Tiredness |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
3.54 [1.40, 8.96] |
| 4.8.16 Unsteadiness |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
1.57 [0.25, 9.81] |
| 4.8.17 Worsening depression |
1 |
140 |
Risk Ratio (M‐H, Fixed, 99% CI) |
1.13 [0.25, 5.07] |
