Carlomagno 2012.

Study characteristics
Methods	Double‐blind RCT
Participants	Women undergoing ICSI (N not stated)
Interventions	1. Myo‐inostol 4 g and folic acid 400 μg: 1 tablet of each a day (n not stated) 2. Folic acid 400 μg: 1 tablet a day (n not stated) Taken for 3 months before ICSI and throughout pregnancy
Outcomes	Total rFSH units Number of stimulation days Fertilisation and cleavage rate Embryo quality Biochemical pregnancy rate Clinical pregnancy rate
Notes	Conducted in Italy, study dates not reported Conference abstract; percentages given but no total participant numbers available Funding by an institutional grant. An author was an employee of a pharmaceutical company Email sent to author 24th November 2015 Gianfranco.carlomagno@gmail.com; no reply.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "Patients were randomly assigned to two groups; MI treated or placebo"
Allocation concealment (selection bias)	Unclear risk	Not mentioned
Blinding (performance bias and detection bias) All outcomes	Low risk	Quote: "Double blind"
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Not mentioned
Selective reporting (reporting bias)	Unclear risk	Trial registration number not available
Other bias	Unclear risk	Conference abstract ‐ baseline numbers unclear