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. 2020 Aug 27;2020(8):CD007807. doi: 10.1002/14651858.CD007807.pub4

Carlomagno 2012.

Study characteristics
Methods Double‐blind RCT
Participants Women undergoing ICSI (N not stated)
Interventions 1. Myo‐inostol 4 g and folic acid 400 μg: 1 tablet of each a day (n not stated)
2. Folic acid 400 μg: 1 tablet a day (n not stated)
Taken for 3 months before ICSI and throughout pregnancy
Outcomes Total rFSH units
Number of stimulation days
Fertilisation and cleavage rate
Embryo quality
Biochemical pregnancy rate
Clinical pregnancy rate
Notes Conducted in Italy, study dates not reported
Conference abstract; percentages given but no total participant numbers available
Funding by an institutional grant. An author was an employee of a pharmaceutical company
Email sent to author 24th November 2015 Gianfranco.carlomagno@gmail.com; no reply.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "Patients were randomly assigned to two groups; MI treated or placebo"
Allocation concealment (selection bias) Unclear risk Not mentioned
Blinding (performance bias and detection bias)
All outcomes Low risk Quote: "Double blind"
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Not mentioned
Selective reporting (reporting bias) Unclear risk Trial registration number not available
Other bias Unclear risk Conference abstract ‐ baseline numbers unclear