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. 2020 Aug 27;2020(8):CD007807. doi: 10.1002/14651858.CD007807.pub4

Hefny 2018.

Study characteristics
Methods Placebo‐controlled double‐blind randomised clinical trial
Participants Infertile women attending an Obstetrics and Gynaecology clinic. Women with PCOS undergoing timed intercourse (Mean age = ?) (N = 200)
Inclusion criteria: PCOS infertile women
Exclusion criteria: Unknown
Interventions 1. Clomiphene citrate 100 mg/day plus NAC 1.2 g/day (N = ?))
2. Clomiphene citrate 100 mg/day plus placebo (N = ?)
Treatment for 5 days starting at day 3 of the cycle
Outcomes The number of follicles > 18 mm on the day of hCG administration
Ovulation rates
The mean endometrial thickness
Pregnancy
No adverse side‐effects and no cases of OHSS were observed in the group receiving NAC
Notes Conference abstract
Location: Obstetrics and Gynaecology, El Hussein University Hospital, Cairo, Egypt
Timeframe: Unkown
Trial registration number: Unkown
Informed consent: Unkown
Ethical approval: Unkown
Sample size power calculation: Unkown
Funding: Unkown
Conflict of interests:Unkown
ITT: Unkown
Author email: Unkown and unable to find
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "Randomly divided"
Allocation concealment (selection bias) Unclear risk Unknown
Blinding (performance bias and detection bias)
All outcomes Low risk Quote: "Placebo‐controlled double‐blind"
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Unknown
Selective reporting (reporting bias) Unclear risk Trial registration number not available
Other bias Unclear risk Conference abstract ‐ baseline characteristics unclear