Sen Sharma 2017.
Study characteristics | ||
Methods | Random controlled trial | |
Participants | Women with PCOS attending Infertility clinic. Timed intercourse. Mean age unknown Inclusion criteria: infertile women with PCOS resistant to treatment with 100 mg CC for 5 days per cycle with persistent anovulation (N = 62) Exclusion criteria: Women with hyperprolactinaemia, thyroid dysfunction or abnormal semen parameters |
|
Interventions | 1. CoQ10 from day 1 of cycle (60 mg thrice daily) + CC 100 mg from day 2 to day 6 of cycle + FSH 75 IU intramuscularly on days 3, 5, 7 and 9 (N = 32) 2. CC 100 mg from day 2 to day 6 + FSH 75 IU intramuscularly on days 3, 5, 7 and 9 of cycle (no treatment) (N = 30) |
|
Outcomes | Size of matured follicle Endometrial thickness Clinical pregnancy Miscarriage rate |
|
Notes | Conference abstract Location: Divisional Railway Hospital, Alipurduar Junction, West Bengal, India Timeframe: Unknown Trial registration number:Unknown Informed consent: Unknown Ethical approval: Unknown Sample size power calculation: Unknown Funding: Unknown Conflict of interests: Unknown ITT: Unknown Author email: Unknown. Dr Debjani SenSharma, unable to find contact details after database, Google and facebook search |
|
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Unknown. Women with "persistent anovulation were randomized either to..." |
Allocation concealment (selection bias) | Unclear risk | Unknown |
Blinding (performance bias and detection bias) All outcomes | High risk | The control is no treatment |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No loss to follow‐up |
Selective reporting (reporting bias) | Unclear risk | Trial registration number unavailable. Does report clinical pregnancy but not live birth |
Other bias | Unclear risk | Conference abstract ‐ baseline characteristics unclear |