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. 2020 Aug 27;2020(8):CD007807. doi: 10.1002/14651858.CD007807.pub4

Sen Sharma 2017.

Study characteristics
Methods Random controlled trial
Participants Women with PCOS attending Infertility clinic. Timed intercourse. Mean age unknown
Inclusion criteria: infertile women with PCOS resistant to treatment with 100 mg CC for 5 days per cycle with persistent anovulation (N = 62)
Exclusion criteria: Women with hyperprolactinaemia, thyroid dysfunction or abnormal semen parameters
Interventions 1. CoQ10 from day 1 of cycle (60 mg thrice daily) + CC 100 mg from day 2 to day 6 of cycle + FSH 75 IU intramuscularly on days 3, 5, 7 and 9 (N = 32)
2. CC 100 mg from day 2 to day 6 + FSH 75 IU intramuscularly on days 3, 5, 7 and 9 of cycle (no treatment) (N = 30)
Outcomes Size of matured follicle
Endometrial thickness
Clinical pregnancy
Miscarriage rate
Notes Conference abstract
Location: Divisional Railway Hospital, Alipurduar Junction, West Bengal, India
Timeframe: Unknown
Trial registration number:Unknown
Informed consent: Unknown
Ethical approval: Unknown
Sample size power calculation: Unknown
Funding: Unknown
Conflict of interests: Unknown
ITT: Unknown
Author email: Unknown. Dr Debjani SenSharma, unable to find contact details after database, Google and facebook search
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Unknown. Women with "persistent anovulation were randomized either to..."
Allocation concealment (selection bias) Unclear risk Unknown
Blinding (performance bias and detection bias)
All outcomes High risk The control is no treatment
Incomplete outcome data (attrition bias)
All outcomes Low risk No loss to follow‐up
Selective reporting (reporting bias) Unclear risk Trial registration number unavailable. Does report clinical pregnancy but not live birth
Other bias Unclear risk Conference abstract ‐ baseline characteristics unclear