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. 2020 Aug 27;2020(8):CD007807. doi: 10.1002/14651858.CD007807.pub4

ChiCTR1800019772.

Study name Effect of omega‐3 fatty acids on oocyte quality and early embryo development in elderly infertile women
Methods Randomised parallel controlled trial
Participants Inclusion criteria:
  • Aged 35 ‐ 42 years

  • Undergo cycle of IVF or ICSI

  • Short‐term ovulation induction

  • Omega‐3 fatty acid were not taken in the past 3 months


Exclusion criteria:
  • Ovarian cyst resection after one‐sided ovariectomy in the past

  • Uterine malformations, such as unilateral uterus, mediastinal uterus, double uterus, double‐horned uterus, etc

  • Abnormal karyotypes (including polymorphism) of the chromosomes of the husband or herself

  • Suffering from diseases that are not suitable for assisted reproductive technology or for current pregnancy

Interventions DHA group: DHA treatment for 6 ‐ 8 weeks;
ALA group: ALA treatment for 6 ‐ 8 weeks;
Placebo group: Placebo treatment for 6 ‐ 8 weeks
Outcomes Primary outcome(s):
DHA and ALA level in serum; DHA and ALA level in follicular fluid; oocyte maturation rate; high‐quality embryo rate
Secondary outcome(s):
Height; weight; waistline; hipline
Starting date ‐1 December 2018
Contact information Ling Geng
Address: 157 Jingliu Road, Jinan, Shandong, China
Telephone:+86 0531‐85651391
Email:gengling@sduivf.com
Affiliation: Center for Reproductive Medicine Affiliated to Shandong University
Tiantian Zhang
Address: 157 Jingliu Road, Jinan, Shandong, China
Telephone: +86 17862963456
Email: zhangtiantian@sduivf.com
Affiliation: Center for Reproductive Medicine Affiliated to Shandong University
Notes Recruitment status: recruiting