ChiCTR1800019772.

Study name	Effect of omega‐3 fatty acids on oocyte quality and early embryo development in elderly infertile women
Methods	Randomised parallel controlled trial
Participants	Inclusion criteria: Aged 35 ‐ 42 years Undergo cycle of IVF or ICSI Short‐term ovulation induction Omega‐3 fatty acid were not taken in the past 3 months Exclusion criteria: Ovarian cyst resection after one‐sided ovariectomy in the past Uterine malformations, such as unilateral uterus, mediastinal uterus, double uterus, double‐horned uterus, etc Abnormal karyotypes (including polymorphism) of the chromosomes of the husband or herself Suffering from diseases that are not suitable for assisted reproductive technology or for current pregnancy
Interventions	DHA group: DHA treatment for 6 ‐ 8 weeks; ALA group: ALA treatment for 6 ‐ 8 weeks; Placebo group: Placebo treatment for 6 ‐ 8 weeks
Outcomes	Primary outcome(s): DHA and ALA level in serum; DHA and ALA level in follicular fluid; oocyte maturation rate; high‐quality embryo rate Secondary outcome(s): Height; weight; waistline; hipline
Starting date	‐1 December 2018
Contact information	Ling Geng Address: 157 Jingliu Road, Jinan, Shandong, China Telephone:+86 0531‐85651391 Email:gengling@sduivf.com Affiliation: Center for Reproductive Medicine Affiliated to Shandong University Tiantian Zhang Address: 157 Jingliu Road, Jinan, Shandong, China Telephone: +86 17862963456 Email: zhangtiantian@sduivf.com Affiliation: Center for Reproductive Medicine Affiliated to Shandong University
Notes	Recruitment status: recruiting