| Study characteristics |
| Methods |
RCT |
| Participants |
87 formula‐fed infants of gestational age at birth 28 to 32 weeks. |
| Interventions |
Probiotics (N = 51): Saccharomyces boulardii added to formula every 12 hours during the 1st week of life when enteral feed are tolerated for 30 days
Control (N = 36): maltodextrin placebo |
| Outcomes |
NEC Death Infection Weight gain |
| Notes |
Greece (period of study: not specified)
Funding: not stated |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Not described |
| Allocation concealment (selection bias) |
Low risk |
Cards with allocation in sealed envelopes |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Masked |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Near‐complete (5 infants with incomplete data were not included in analyses) |
| Selective reporting (reporting bias) |
Low risk |
Unlikely |
