Lin 2008.

Study characteristics
Methods	RCT
Participants	434 VLBW infants
Interventions	Probiotics (N = 217): Bifidobacterium bifidum and Lactobacillus acidophilus, added to human milk or formula 2 times daily for 6 weeks Control (N = 217): unsupplemented milk feeds
Outcomes	NEC Death Infection
Notes	Taiwan (7 centres: 2005 to 2007) Funding: National Science Council of Taiwan ClinicalTrials.gov Identifier: NCT00540033
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated
Allocation concealment (selection bias)	Low risk	Allocated centrally
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unsupplemented milk feeds‐ not placebo‐controlled
Incomplete outcome data (attrition bias) All outcomes	Low risk	Complete
Selective reporting (reporting bias)	Low risk	Unlikely