Serce 2013.

Study characteristics
Methods	RCT
Participants	208 very preterm or VLBW infants
Interventions	Probiotics (N = 104): Saccharomyces boulardii in human milk or formula once daily until discharge from hospital Control (N = 104): unsupplemented milk feeds
Outcomes	NEC Death Infection Rate of weight gain Duration of hospitalisation Culture proven Saccharomyces boulardii (quote:) "sepsis"
Notes	Turkey (2010 to 2011) Funding: Biocodex supplied the intervention
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated
Allocation concealment (selection bias)	Low risk	Opaque, sequentially‐numbered, sealed envelopes.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unsupplemented milk feeds‐ not placebo‐controlled
Incomplete outcome data (attrition bias) All outcomes	Low risk	Complete
Selective reporting (reporting bias)	Low risk	Unlikely