Shashidhar 2017.

Study characteristics
Methods	RCT
Participants	104 VLBW infants
Interventions	Probiotics (N = 52): Lactobacillus acidophilus, L. rhamnosus, Bifidobacterium longum and Saccharomyces boulardii (Darolac) once daily in human milk until discharge from hospital Control (N = 52): unsupplemented milk feeds
Outcomes	NEC Death Duration of hospital stay
Notes	India (2012 to 2013) Funding: not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated
Allocation concealment (selection bias)	Low risk	Sequentially‐numbered, opaque. sealed envelopes
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unsupplemented milk feeds‐ not placebo‐controlled
Incomplete outcome data (attrition bias) All outcomes	Low risk	Near‐complete (3 infants in each group withdrawn)
Selective reporting (reporting bias)	Low risk	Unlikely