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. 2009 Feb 19;20(1):200–210. doi: 10.1111/j.1750-3639.2009.00267.x

Figure 3.

Figure 3

Aminopeptidase N (APN) inhibition in meningioma cells do not affect meningioma cell proliferation. A. Significant inhibition of APN mRNA (left figure; ***P < 0.01) and protein levels (right figure) by two different siRNA species. B. Both Ben‐Men‐1 and IOMM‐Lee cells have reduced APN enzymatic activity following siRNA‐mediated knockdown [mean ± standard error of the mean (SEM); *P < 0.05]. C. No substantial effects on meningioma cell proliferation are seen after inhibition by APN inhibitors (actinonin, PAQ22 or WM15) or by siRNA (mean ± SEM are shown for IOMM‐Lee cells).