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. 2021 Mar 17;2021(3):CD001894. doi: 10.1002/14651858.CD001894.pub6

Ng 2005.

Study characteristics
Methods Randomised trial
Participants 160 women from Hong Kong with frozen embryo transfer
Mean age: 34.0 years
Interventions Laser‐assisted thinning 1/4 with frozen embryos compared to frozen embryos
AH: 80 women
Control: 80 women
Outcomes Clinical pregnancy, miscarriage, multiple pregnancy rates
Notes No study author contact as all details clearly stated in article
No. of embryos stated: AH, transferred 2 in 52.5% and 3 in 41.3%; control, transferred 2 in 36.2% and 3 in 61.3%
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated randomisation
Allocation concealment (selection bias) Unclear risk 'Sealed envelopes' used but unclear if these were opaque and how they were numbered
Blinding (performance bias and detection bias)
All outcomes Low risk Double‐blinding until completion of the study
Incomplete outcome data (attrition bias)
All outcomes Low risk No evidence of attrition bias
Selective reporting (reporting bias) Unclear risk Original protocol not viewed. Study authors did not report on live birth
Other bias Low risk None identified