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. 2021 Mar 17;2021(3):CD001894. doi: 10.1002/14651858.CD001894.pub6

Sagoskin 2007.

Study characteristics
Methods Randomised trial
Participants 199 women from USA undergoing IVF or ICSI
Good prognosis group with only 1 previous implantation failure
Fresh embryo transfer cycles only
Interventions Laser hatching (breach with hole)
AH: 121 randomised, 118 analysed, 254 embryos; control: 82 randomised, 81 analysed, 170 embryos
Outcomes Live birth, clinical pregnancy, miscarriage, multiple pregnancy rates
Notes No study author contacted as all details clearly stated in article
ET: AH 2.2 (0.4); control 2.1 (0.3)
Power calculation not reported
Published as a full paper
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Treatment assignments were determined by a computer‐generated randomised series at a 3:2 ratio of treatments to controls
Allocation concealment (selection bias) Unclear risk Not stated within text
Blinding (performance bias and detection bias)
All outcomes Unclear risk Not stated within text
Incomplete outcome data (attrition bias)
All outcomes Unclear risk ITT unclear
Selective reporting (reporting bias) Low risk Live birth reported
Other bias Low risk None identified