Sagoskin 2007.
Study characteristics | ||
Methods | Randomised trial | |
Participants | 199 women from USA undergoing IVF or ICSI Good prognosis group with only 1 previous implantation failure Fresh embryo transfer cycles only | |
Interventions | Laser hatching (breach with hole) AH: 121 randomised, 118 analysed, 254 embryos; control: 82 randomised, 81 analysed, 170 embryos | |
Outcomes | Live birth, clinical pregnancy, miscarriage, multiple pregnancy rates | |
Notes | No study author contacted as all details clearly stated in article ET: AH 2.2 (0.4); control 2.1 (0.3) Power calculation not reported Published as a full paper |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Treatment assignments were determined by a computer‐generated randomised series at a 3:2 ratio of treatments to controls |
Allocation concealment (selection bias) | Unclear risk | Not stated within text |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Not stated within text |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | ITT unclear |
Selective reporting (reporting bias) | Low risk | Live birth reported |
Other bias | Low risk | None identified |