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. 2021 Mar 17;2021(3):CD001894. doi: 10.1002/14651858.CD001894.pub6

Stein 1995.

Study characteristics
Methods Single‐centre randomised trial
Participants 154 women from Israel with repeated implantation failure (> 3 attempts) undergoing IVF
Mean age not stated
Interventions AH (mechanical; complete zona breach; ? hour egg retrieval to AH; 1.5 hour AH to transfer) vs no AH
AH: 72 women randomised, 230 embryos transferred
Control: 82 women randomised, 295 embryos transferred
Outcomes Clinical pregnancy, miscarriage
Notes Attempted to contact author about this study; no reply received
Unclear whether power calculation performed
ITT analysis unclear
Published as full paper
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Randomisation stated but method unclear or incorrect
Allocation concealment (selection bias) Unclear risk Unclear; no details
Blinding (performance bias and detection bias)
All outcomes Unclear risk Participants not blinded or unclear
Assessor not blinded or unclear
Incomplete outcome data (attrition bias)
All outcomes Unclear risk ITT analysis unclear
Selective reporting (reporting bias) High risk Original protocol not viewed but study authors did not report on live birth
Other bias Low risk None identified