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. 2021 Mar 17;2021(3):CD001894. doi: 10.1002/14651858.CD001894.pub6

Tucker 1996.

Study characteristics
Methods Single‐centre randomised trial
Participants 100 women from North America undergoing ICSI
Mean age: control group 33.5 (4.3); AH group 35.3 (4.2)
Interventions AH with acid Tyrode's (chemical; complete zona breach; 72 hour egg retrieval to AH; 4 hour AH to transfer) vs no AH
AH: 50 women randomised, 189 embryos transferred
Control: 50 women randomised, 184 embryos transferred
Outcomes Implantation, clinical pregnancy
Notes Attempted to contact author about this study; no reply received
ET: AH 3.7, control 3.8
Unclear whether power calculation performed
ITT analysis unclear
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Randomisation stated but method unclear or incorrect
Allocation concealment (selection bias) Unclear risk Allocation concealment unclear
Blinding (performance bias and detection bias)
All outcomes Unclear risk Participants not blinded or unclear
Assessor not blinded or unclear
Incomplete outcome data (attrition bias)
All outcomes Low risk Women randomised appear to be analysed
Selective reporting (reporting bias) Unclear risk Original protocol not viewed but study authors did not report on live birth
Other bias Low risk None identified