Table 3.
Immunoglobulin‐related genes upregulated among multiple sclerosis patients. Abbreviations: AB = Applied Biosystems; n.d. = not detected by qPCR; qPCR = quantitative polymerase chain reaction; SAM = significance analysis of microarrays.
| Celera gene ID | Gene symbol | Gene name | AB probe ID | SAM q‐value | TaqMan ID | qPCR P‐value | Panther family name |
|---|---|---|---|---|---|---|---|
| hCG2041292 | 178480 | 0.0 | Immunoglobulin gamma heavy chain constant region (PTHR23266:SF4) | ||||
| hCG2038926 | IGHG1 | Immunoglobulin heavy constant gamma 1 | 191229 | 1.0 | Hs00378230_g1 | 1.3E‐02 | |
| hCG2003479 | IGHG3 | Immunoglobulin heavy constant gamma 3 | 121996 | 1.6 | |||
| hCG1988537 | 220939 | 3.1 | Immunoglobulin heavy chain variable region (PTHR23266:SF11) | ||||
| hCG1793614* | IGHM | Immunoglobulin heavy constant mu | 179702 | 0.0 | Immunoglobulin heavy chain variable region VH‐II (PTHR23266:SF7) | ||
| 102721 | 0.0 | ||||||
| hCG2038924 | 206632 | 0.0 | |||||
| hCG2038932 | 138080 | 0.0 | |||||
| hCG1794122 | 236107 | 0.0 | |||||
| hCG2038943 | 154783 | 1.0 | |||||
| hCG1812074 | VSIG6 | V‐set and immunoglobulin domain containing 6 | 102138 | 0.0 | Hs00868452_g1 | n.d. | |
| hCG2038940* | 113811 | 0.0 | Hs01635161_gH | n.d. | Immunoglobulin heavy chain variable region VH‐III (PTHR23266:SF10) | ||
| 123277 | 1.0 | ||||||
| hCG1773456 | 188651 | 0.0 | Hs01635150_gH | n.d. | |||
| 202646 | 2.9 | ||||||
| hCG2038923 | LOC90925* | Hypothetical protein LOC90925 | 193687 | 0.0 | |||
| hCG2038931 | 108776 | 1.8 | |||||
| hCG1812069 | LOC388248 | 141132 | 0.0 | ||||
| hCG2038939 | 181990 | 1.0 | |||||
| hCG2003024 | VSIG7 | V‐set and immunoglobulin domain containing 7 | 188579 | 2.4 | |||
| hCG2038930 | 126586 | 3.0 | |||||
| hCG1980528* | IGKC | Immunoglobulin kappa constant | 112729 | 0.0 | Hs01692073_s1 | 4.1E‐03 | Immunoglobulin lambda chain C region (PTHR23267:SF1) |
| 177583 | 0.0 | ||||||
| 165736 | 2.1 | ||||||
| hCG1742442 | 175634 | 0.0 | Hs01593416_g1 | n.d. | Immunoglobulin kappa light chain V region (PTHR23267:SF33) | ||
| hCG2042707 | 136785 | 0.0 | Hs01847594_sH | 1.4E‐01† | |||
| hCG1791795 | 134541 | 0.0 | |||||
| hCG1642538 | LOC440786 | Hypothetical LOC440786 | 183428 | 1.0 | |||
| hCG1749806 | IGKV4‐1 | Immunoglobulin kappa variable 4‐1 | 135354 | 1.6 | Hs00863339_g1 | 6.2E‐03 | |
| hCG1642807 | 125874 | 2.7 | |||||
| hCG2042722 | 161488 | 3.0 | |||||
| hCG2043208 | 152990 | 4.1 | |||||
| hCG1789507 | 172955 | 4.5 |
*
Gene is targeted by several upregulated probes.
†
Gene was only detected in a fraction of the samples, but a strong upregulation among multiple sclerosis patients was clearly indicated.