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Immunoblotting of the sarkosyl‐insoluble fraction (SarkI‐P) from spinal cord specimens of amyotrophic lateral sclerosis patients (ALS) and control (ctrl) with antibodies to TDP‐43 (A) and ubiquitin (B). The 43 kDa band corresponds to full‐length TDP‐43; the 45 and 28 kDa bands are pathological TDP‐43 forms; the TDP‐43‐immunostained protein bands below 43 kDa are presumably cleavage products of TDP‐43 (29). (*) High‐molecular mass smear.
