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. 2009 Jan 5;20(1):96–105. doi: 10.1111/j.1750-3639.2008.00249.x

Figure 3.

Figure 3

Repressor element‐1 silencing transcription factor/neuron‐restrictive silencer factor (REST/NRSF) occupancy of the repressor element‐1/neuron‐restrictive silencer element (RE1/NRSE) locus of the leukocyte immunoglobulin‐like receptor, subfamily B, member 4 (LILRB4) gene. A. REST/NRSF occupancy of the RE1/NRSE locus of the LILRB4 gene in control (CT), pre‐Huntington's disease (HD), HD and spinocerebellar ataxia type 1, 2, and 6 (SCA type 1, 2 and 6) subjects. Each column represents the average value ± standard deviation of three independent quantitative polymerase chain reaction experiments using genomic DNA immunoprecipitated with anti‐REST/NRSF antibody. B. Median REST/NRSF occupancy in the CT and HD groups. REST/NRSF occupancy was significantly greater in the HD patients than in the CT (two‐tailed Mann–Whitney test: P = 0.0003), and in the pre‐HD (Kruskal–Wallis test: P < 0.01) and SCA subjects (Kruskal–Wallis test: P < 0.05), with no statistical difference between the CT and pre‐HD (Kruskal–Wallis test: P > 0.05) or spinocerebellar ataxia (SCA) samples (Kruskal–Wallis test: P > 0.05). The boundary of the box closest to zero indicates the 25th percentile, the line within the box marks the median and the boundary of the box farthest from zero indicates the 75th percentile. When 10 or more samples were analyzed, whiskers above and below the box indicate the 90th and 10th percentiles. Outliers are indicated as black circles. Abbreviations: IgG = immunoglobulin G.