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. 2009 Jan 5;20(1):96–105. doi: 10.1111/j.1750-3639.2008.00249.x

Figure 4.

Figure 4

Repressor element‐1 silencing transcription factor/neuron‐restrictive silencer factor (REST/NRSF) occupancy at the repressor element‐1/neuron‐restrictive silencer element (RE1/NRSE) of the immunoglobulin lambda‐like polypeptide 1 precursor (IGLL1) gene. A. REST/NRSF occupancy of the RE1/NRSE of the IGLL1 gene. Each column represents the average value ± standard deviation of three independent quantitative polymerase chain reaction experiments. B. Median REST/NRSF occupancy levels in the control (CT) and Huntington's disease (HD) groups. RE1/NRSE occupancy was significantly greater in the HD patients than in the CT (two‐tailed Mann–Whitney test: P = 0.0002), and in the pre‐HD (Kruskal–Wallis test: P < 0.01) and spinocerebellar ataxia (SCA) subjects (Kruskal–Wallis test: P < 0.05), with no statistical difference between the CT and the pre‐HD (Kruskal–Wallis test: P > 0.05) or SCA subjects (Kruskal–Wallis test: P > 0.01). The boundary of the box closest to zero indicates the 25th percentile, the line within the box marks the median and the boundary of the box farthest from zero indicates the 75th percentile. When 10 or more samples were analyzed, whiskers above and below the box indicate the 90th and 10th percentiles. Outliers are indicated as black circles.