| Reference |
Unit of randomisation |
Reported |
Definition |
Otoscopically confirmed? |
Time points |
Notes |
|
Baba 1982c
|
Person |
Person |
Resolution of ear discharge |
Unclear |
1 to 2 weeks (7 days) |
The worst affected ear was selected as the study ear. When both sides were equal, the right side was selected. |
| Bajwa 2018 |
Person |
Person |
"Cured" as non‐existence of the otorrhoea or otoscopically dormant (no discharge pooling; non‐swollen middle ear mucosa) or existence of serous mucous otorrhoea with bacteriological culture negative after therapy period |
Unclear |
1 to 2 weeks (2 weeks), 2 to 4 weeks (3 weeks), after 4 weeks (8 weeks) |
— |
|
de Miguel 1999
|
Person |
Person |
"Global index of clinic microbiological cure" |
Yes |
1 to 2 weeks (7 days) |
— |
| Eason 1986 |
Person |
Ear |
"Dry" or "not discharging" |
Yes |
2 to 4 weeks (3 weeks), after 4 weeks (6 weeks) |
Bilateral ears counted separately. Results not used as it was not possible to account for correlation between ears due to bilateral disease. |
| Esposito 1990 |
Person |
Person |
"Clinically cured" |
Unclear |
1 to 2 weeks (6 to 11 days), 2 to 4 weeks (19 to 24 days) |
The 1‐ to 2‐week outcome was examined but not reported |
| Fliss 1990 |
Person |
Person |
Complete resolution of ear discharge |
Yes |
1 to 2 weeks (9 days), 2 to 4 weeks (18 days) |
Time points unclear |
| Ghosh 2012 |
Person |
Person |
“Clinical cure” if the otological symptom score was < 3 at day 14 visit |
Unclear |
1 to 2 weeks (14 days) |
— |
| Minja 2006 |
School |
Person |
"Dry ear" |
Yes |
2 to 4 weeks (1 month), after 4 weeks (3 to 4 months) |
Patients with bilateral ear disease were only counted as dry ears if both ears were dry |
| Nwokoye 2015 |
Person |
Person |
"Recovery" (no further details provided) |
Yes |
1 to 2 weeks (time point unclear; treatment for 7 to 10 days), 2 to 4 weeks (time point unclear) |
— |
|
Onali 2018
|
Person
|
Person |
"Resolution of discharge" |
Unclear
|
1 to 2 weeks (7 days) |
— |
|
Picozzi 1984
|
Person |
Person |
"Inactive" (no further details provided) |
Unclear |
After 4 weeks (4 weeks) |
— |
|
Ramos 2003
|
Person |
Person |
"Cured" according to "indices de curacion" |
Yes |
2 to 4 weeks (10 days) |
— |
|
Renukananda 2014
|
Person |
Person |
"Cured" as absence of otorrhoea or otoscopically inactive, i.e. no pooling of discharge, non‐inflamed middle ear mucosa |
Yes |
1 to 2 weeks (2 weeks)
|
33/100 participants had bilateral disease. Unclear how these were assessed for resolution of ear discharge. |
|
Rotimi 1990
|
Person |
Person |
"Clinical response" defined as cessation of discharge with no hyperaemic areas in the mucosa
"Inactive" defined as the ear being completely dry, or "cured", defined as inactive with culture sterile and non‐hyperaemic mucosa |
Unclear |
1 to 2 weeks (1 week), 2 to 4 weeks (3 weeks), after 4 weeks (6 weeks) |
Patients with bilateral ear disease were only counted as resolved if both ears were dry.
|
|
Sambe 1977
|
Person |
Person |
Disappearance of otorrhoea or reduction of ear leak |
Yes |
1 to 2 weeks (14 days) |
— |
|
Sanchez Gonzales 2001
|
Person |
Person |
Not reported |
Unclear |
1 to 2 weeks (10 days, 12 days), 2 to 4 weeks (15 days), after 4 weeks (4 weeks) |
— |
|
Somekh 2000
|
Person |
Person
|
"Complete disappearance of ear discharge within the period of treatment"
|
Unclear |
1 to 2 weeks (14 days) |
— |
|
Van der Veen 2007
|
Person |
Person
|
"No otomicroscopic sign of otorrhoea at either ear" |
Yes |
After 4 weeks (6 weeks, 12 weeks, 1 year)
|
Patients with bilateral ear disease were only counted as resolved if both ears were dry. |
