Table 2.

Summary of main neuropathological findings related with tau pathology. Involvement of three combined regions, presence of tufted astrocytes and AGD changes are expressed semiquantitative ly. +: mild; ++: moderate; +++: severe; +/− indicates lack of involvement of one of the mentioned regions. Abbreviation: AGD = argyrophilic grain disease.

Cases/region affected	1	2	3	4	5
Caudate/putamen	+	+	+	+	++
Globus pallidus/subthalamus	+/−	+/−	++/+	+	++
Substantia nigra/coeruleus/colliculi/ventral pons	+/−	+/−	+	++/+	+++/++
Tufted astrocytes	no	exceptional	very rare	occasional	very common
AGD stage	2	2	3	3	3