| Study |
Outcome |
Experimental group |
Control group |
Statistic |
Comments |
| n |
Mean |
SD |
n |
Mean |
SD |
| Overall |
| Barratt 1997 |
Frequency of aggressive acts per week at 6 weeks |
60 |
0.33 |
No data |
60 |
0.51 |
No data |
F1, 58 = 9.64 (repeated measure ANOVA, Greenhouse‐Geisser adjusted; P < 0.001) |
Favours phenytoin |
|
Barratt 1997 |
Intensity of aggressive acts per week at 6 weeks |
60 |
2.61 |
No data |
60 |
3.96 |
No data |
F1, 58 = 8.23 (repeated measure ANOVA, Greenhouse‐Geisser adjusted; P < 0.01) |
Favours phenytoin |
| Impulsive aggression subgroup |
|
Barratt 1997 |
Frequency of aggressive acts per week at 6 weeks |
30 |
0.20 |
0.19 |
30 |
0.52 |
0.46 |
Subgroup effect (impulsive vs non‐impulsive): F1, 58 = 9.21 (repeated measure ANOVA, Greenhouse‐Geisser adjusted; P < 0.01) |
Favours phenytoin |
| Subgroup by drug‐placebo effect: F1, 58 = 9.50 (repeated measure ANOVA, Greenhouse‐Geisser adjusted; P < 0.01) |
| Barratt 1997 |
Intensity of aggressive acts per week at 6 weeks |
30 |
2.11 |
1.20 |
30 |
4.16 |
1.92 |
Subgroup effect (impulsive vs non‐impulsive): F1, 58 = 4.78 (repeated measure ANOVA, Greenhouse‐Geisser adjusted; P < 0.05) |
Favours phenytoin |
| Subgroup by drug‐placebo effect: F1, 58 = 9.74 (repeated measure ANOVA, Greenhouse‐Geisser adjusted; P < 0.01) |
| Non‐impulsive aggression subgroup |
| Barratt 1997 |
Frequency of aggressive acts per week at 6 weeks |
30 |
0.42 |
0.24 |
30 |
0.51 |
0.48 |
Subgroup effect (impulsive vs non‐impulsive): F1, 58 = 9.21 (repeated measure ANOVA, Greenhouse‐Geisser adjusted; P < 0.01) |
Favours neither condition |
| Subgroup by drug‐placebo effect: F1, 58 = 9.50 (repeated measure ANOVA, Greenhouse‐Geisser adjusted; P < 0.01) |
| Barratt 1997 |
Intensity of aggressive acts per week at 6 weeks |
30 |
3.40 |
1.29 |
30 |
3.76 |
1.59 |
Subgroup effect (impulsive vs non‐impulsive) F1, 58 = 4.78 (repeated measure ANOVA, Greenhouse‐Geisser adjusted; P < 0.05) |
Favours neither condition |
| Subgroup by drug‐placebo effect: F1, 58 = 9.74 (repeated measure ANOVA, Greenhouse‐Geisser adjusted; P < 0.01) |
|
ANOVA: Analysis of variance; SD: standard deviation. |
