8. Comparison 5. Desipramine versus placebo: substance misuse.

Study	Outcomea	Experimental group (n = 17 completed)	Control group (n = 12 completed)	Statisticc
Arndt 1994	ASI (drug factor scores)b	0.259	0.23	Favours neither condition (P > 0.05)
Arndt 1994	Days of opiate use	2	2	Favours neither condition (P > 0.05)
Arndt 1994	Days of cocaine use	9	8	Favours neither condition (P > 0.05)
Arndt 1994	Cocaine craving scores	8	7	Favours neither condition (P > 0.05)
ANCOVA: Analysis of covariance; ASI: Addiction Severity Index

^a12‐week end of treatment means
^bASI factor scores range from 0 to 1 with larger values indicating greater problem severity
^cBetween‐groups ANCOVA using baseline value as covariate; baseline values reflect the 30 days before start of treatment; analysis carried out by trial investigators