Breneman 1992.

Study characteristics
Methods	Study design: parallel RCT Time frame: 1992 Duration of study/follow‐up: 6 weeks
Participants	Setting: single centre (inpatients) Country: USA Inclusion criteria: undergoing HD for at least 1 month and had been experiencing moderate to severe pruritus not attributable to other definable cutaneous or medical conditions Number: 21 (number per group not reported) Age range: 22 to 77 years Sex (M/F): 12/9 Relevant comorbidities: not reported Exclusion criteria: not reported
Interventions	Treatment group Capsaicin cream (topical): 0.025% cream, 4 times/day for 16 weeks Control group Placebo cream (topical): daily for 16 weeks
Outcomes	Pruritus: Duo score Adverse effects
Notes	Conflicts of interest: not declared Debra L. Breneman, MD, University of Cincinnati, Department of Dermatology, 234 Goodman St., Cincinnati, OH 45267‐0523
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	QUOTE: "randomised"
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double blind
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Double blind
Incomplete outcome data (attrition bias) All outcomes	High risk	Multiple patient dropouts
Selective reporting (reporting bias)	High risk	No statistics reported
Other bias	Low risk	No evidence for publication or funding bias