Gunal 2004.

Study characteristics
Methods	Study design: cross‐over RCT Time frame: not reported Duration of study/follow‐up: 8 weeks
Participants	Setting: single centre (inpatients) Country: Turkey Health status: ESKD on HD; minimum duration of pruritus 8 weeks Number: 25 Mean age ± SD: 55 ± 11 years Sex (M/F): 14/11 Relevant comorbidities: not reported Exclusion criteria: concomitant dermatological, liver, or metabolic diseases associated with pruritus.
Interventions	Treatment group Gabapentin (oral): 300 mg, 3 times/week for 4 weeks Control group Placebo (oral): 3 times/week for 4 weeks
Outcomes	Mean pruritis score: VAS daily with mean reported at baseline and end of the treatment period
Notes	No declared source of funding Correspondence: Dr. Ali Ihsan Gunal; Firat University, 23200 Elazig, Turkey; igunal@yahoo.com
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	QUOTE: "On a random and blinded basis, patients were assigned to"
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgment
Blinding of participants and personnel (performance bias) All outcomes	Low risk	QUOTE: "On a random and blinded basis, patients were assigned", "We conducted a double‐blind,"
Blinding of outcome assessment (detection bias) All outcomes	Low risk	QUOTE: "double‐blinded", "The daily pruritus scores of patients were collected VAS from patient diaries.", "On a random and blinded basis, patients were assigned"
Incomplete outcome data (attrition bias) All outcomes	Low risk	All enrolled patients completed the trial and were analysed. Multiple 1 week washout periods preceding intervention and control periods.
Selective reporting (reporting bias)	Unclear risk	All entered patients completed the trial and were analysed Both periods combined reported with mean change and standard deviations reported in full Intervention level data without patient level comparisons provided. Correlation may inflate standard error. Carry‐over effects unlikely due to washout periods
Other bias	Low risk	No intervention first group (however 1 week washout). No evidence of publication, funding, or other confounding bias