Outcomes measured	Assessment scales
Cognitive	The Alzheimer's DIsease Assessment Scale‐Cognitive Subscale (ADAS‐Cog/11) Rosen 1984 The Alzheimer's Disease Assessment Scale–Cognitive Subscale plus Concentration and Distractability and Delayed Word Recall items (ADAS‐Cog/13) Mohs 1997 The non‐memory Alzheimer's Disease Assessment Scale–Cognitive Subscale (ADAS‐Cog/10) The memory Alzheimer's Disease Assessment Scale–Cognitive Subscale (ADAS‐Cog/mem) Baylor Profound Mental State Examination (BPSME) Doody 1999 Mini‐Mental State Examination (MMSE) Folstein 1975 Standardised Mini‐Mental State Examination (SMMSE) Molloy 1991 Severe Impairment Battery (SIB) Saxton 1990
Functional	Alzheimer's Disease Cooperative Study‐Activities of Daily Living Inventory, modified for severe dementia (ADCS‐ADL‐sev) Galasko 2005 Barthel Index of Activities of Daily Living Wade 1988 Bristol Activities of Daily Living Scale (BADLS) Bucks 1996 Disability Assessment for Dementia (DAD) Gelinas 1999 Functional Assessment Staging scale (FAST) Reisberg 1988
Neuropsychiatric	Apathy Evaluation Scale (AES) Marin 1991 Cohen‐Mansfield Agitation Inventory (CMAI) Cohen‐Mansfield 1988 Cornell Depression Scale for Dementia (CDSD) Alexopoulos 1988 Neuropsychiatric Inventory (NPI) Cummings 1994 Neuropsychiatric Inventory‐Nursing Home version (NPI‐NH) Iverson 2002 Neuropsychiatry Inventory caregiver Distress (NPI‐D) Kaufer 1998
Global	Clinical Interview Based Impression of Changes‐Plus Caregiver Input (CIBIC‐Plus) Schneider 1997 Clinician's Global Impression (CGI) Guy 1976 Clinician's Global Impression of Change (CGI‐C) Guy 1976 Clinical Dementia Rating Sum of Boxes score (CDR‐SB) Morris 1993
Quality of Life	General Health Questionnaire (GHQ‐12) Goldberg 1997 Dementia Quality of Life Proxy Measure (DEMQOL‐Proxy) Smith 2005 EuroQol‐5 Dimension (EuroQoL EQ‐5D) Quality of Life in late stage Dementia (QUALID) Weiner 2000
Adverse events, safety and tolerability	Udvaig for Kliniske Undersogelser Seide Effect Rating Scale (UKU SERS Clin) Lingjaerde 1987
Institutionalisation	Client Service Receipt Inventory (CSRI) Beecham 2001