Table 1.
Analysis of small-angle X-ray scattering data for HBV wild-type (wt) and mutant (mut) core promoter oligomer samples
| Parameters | wt | G1738 A | G1748A | G1738/1748A |
|---|---|---|---|---|
| Mw (kDa) | 7.30 | 7.28 | 7.28 | 7.26 |
| I(0)a | 0.0035 ± 1.1 x 10-5 | 0.0041 ± 1.3 x 10-5 | 0.0031 ± 1.6 x 10-5 | 0.0037 ± 2.1 x 10-5 |
| q.Rg range | 0.24–1.30 | 0.23–1.30 | 0.23–1.30 | 0.23–1.29 |
| Rg (Å)a | 18.37 ± 0.11 | 19.10 ± 0.11 | 20.10 ± 0.19 | 20.34 ± 0.22 |
| I(0)a,b | 0.0034 ± 0.7 x 10-5 | 0.0039 ± 1.0 x 10-5 | 0.0030 ± 1.2 x 10-5 | 0.0036 ± 1.7 x 10-5 |
| Rg (Å)b | 17.18 ± 0.03 | 18.17 ± 0.04 | 19.77 ± 0.09 | 20.43 ± 0.10 |
| Dmax (Å)b | 46.85 | 53.14 | 60 | 60.44 |
| χ2c | ∼1.80 | ∼1.50 | ∼1.50 | ∼1.20 |
| NSDc | 0.55 ± 0.01 | 0.58 ± 0.03 | 0.58 ± 0.01 | 0.59 ± 0.01 |
The molecular weight (Mw) values were calculated using nucleotide sequences.
The error calculation for each SAXS data analysis step is described by individual packages implemented in ATSAS suite (55, 84, 89, 90).
a
Obtained from Guinier analysis (91).
b
Determined using P(r) analysis using the GNOM program (55).