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. 2020 Dec 27;2020(12):CD013542. doi: 10.1002/14651858.CD013542.pub2

Ramya 2014.

Study characteristics
Methods Randomised controlled trial
Participants 69 stable VLBW infants (1000–1500 g birth weight)
Setting: Madras Medical College, Chennai, Tamil Nadu, India
Interventions Intervention (n = 34): full enteral feeds (60 mL/kg/day) with expressed maternal milk or donor breast milk
Control (n = 35): minimal enteral feeds (20–40 mL/kg/day) supplemented with parenteral nutrition
Feed volumes advanced by 20 mL/kg/day as tolerated
Outcomes
  1. Days to regain birth weight

  2. Feed intolerance (feeds ceased for prefeed gastric aspirates > 50% of prior feed volume, increase in abdominal girth > 2 cm, visible dilated bowel loops or significant emesis, blood tinged or coffee ground aspirate)

  3. Necrotising enterocolitis (Bell's criteria)

  4. Invasive infection

  5. Duration of hospital stay

Notes Nutrient fortifiers not used.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated.
Allocation concealment (selection bias) Low risk Sealed opaque envelopes.
Blinding of participants and personnel (performance bias)
All outcomes High risk Not masked.
Blinding of outcome assessment (detection bias)
All outcomes High risk Not masked.
Incomplete outcome data (attrition bias)
All outcomes Low risk Complete.
Selective reporting (reporting bias) Unclear risk No protocol.
Other bias Unclear risk Study for dissertation submitted to University for DM (Neonatology).
No funding source reported.