1. Description of the interventions.
| Study | Intervention(s) (route, frequency, total dose/day) | Comparator(s) (route, frequency, total dose/day) |
| Ahn 1996 | I1: fluoxetine 20 mg daily for first 1 week and 40 mg daily for remaining 5 weeks after breakfast | C1: placebo daily |
| Athanasios 2007 | I1: duloxetine 20 mg daily for 1 week followed by 40 mg daily | C1: placebo daily |
| Atmaca 2002 | I1: citalopram 20 mg daily up to 60 mg | C1: placebo daily up to 3 tablets |
| Biri 1998 | I1: sertraline 50 mg daily | C1: placebo daily |
| Buvat 2009 | I1: dapoxetine 30 mg on‐demand I2: dapoxetine 60 mg on‐demand |
C1: placebo daily C2: placebo daily |
| Farnia 2009 | I1: citalopram 20 mg on‐demand | C1: placebo on‐demand |
| Gameel 2013 | I1: paroxetine 20 mg on‐demand + lubricating jelly | C1: placebo on‐demand + lubricating jelly |
| Gong 2011 | I1: paroxetine 20 mg daily | C1: placebo |
| Hamidi Madani 2016 | I1: tramadol 50 mg I2: paroxetine 20 mg |
C1: placebo daily |
| Kara 1996 | I1: fluoxetine 20 mg daily | C1: placebo daily |
| Kaufman 2009 | I1: dapoxetine 60 mg on‐demand | C1: placebo daily |
| Khelaia 2012 | I1: paroxetine 20 mg I2: paroxetine 20 mg 2–3 hours before intercourse |
C1: placebo daily |
| Kim 1998 | I1: fluoxetine 40 mg daily for 1 week then 80 mg for 3 weeks I2: sertraline 100 mg for 1 week then 200 mg for 3 weeks |
C1: placebo daily C2: placebo daily |
| Mattos 2008 | I1: fluoxetine 90 mg daily I2: fluoxetine 90 mg daily + tadalafil 20 mg on‐demand |
C1: placebo daily C2: placebo + tadalafil 20 mg on‐demand |
| McMahon 1998 | I1: sertraline 50 mg daily | C1: placebo daily |
| McMahon 1999 | I1: paroxetine 20 mg I2: paroxetine as needed 3–4 hours before planned sexual intercourse I3: paroxetine 10 mg for 3 weeks then 20 mg paroxetine as needed for 4 weeks |
C1: placebo daily for 3 weeks then placebo daily for 4 weeks |
| McMahon 2010 | I1: dapoxetine 30 mg daily I2: dapoxetine 60 mg daily |
C1: placebo daily C2: placebo daily |
| McMahon 2013 | I1: dapoxetine 30 mg on‐demand, from week 4 up to 60 mg if tolerated + PDE5 inhibitor | C1: placebo on‐demand + PDE5 inhibitor |
| Mendels 1995 | I1: sertraline 50 mg daily that could be titrated up to 200 mg daily | C1: placebo daily |
| Na 1996 | I1: sertraline 50 mg at night that could be titrated up to 100 mg daily | C1: placebo daily |
| Novaretti 2002 | I1: fluoxetine 20 mg daily | C1: placebo daily |
| Pryor 2006 | I1: dapoxetine 30 mg on‐demand I2: dapoxetine 60 mg on‐demand |
C1: placebo on‐demand 1–3 hours before anticipated sexual activity |
| Safarinejad 2006b | I1: dapoxetine 60 mg daily I2: paroxetine 20 mg daily |
C1: placebo daily |
| Safarinejad 2006c | I1: citalopram 20 mg daily | C1: placebo daily |
| Safarinejad 2007 | I1: escitalopram 10 mg daily | C1: placebo daily |
| Safarinejad 2008 | I1: dapoxetine 30 mg twice daily | C1: placebo twice daily |
| Shang 2012 | I1: citalopram 20 mg daily | C1: placebo daily |
| Tuncel 2008 | I1: sertraline 50 mg nightly for 2 months | C1: placebo daily for 2 months |
| Waldinger 1994 | I1: paroxetine 20 mg daily for 1 week and then 40 mg daily from week 2–6 | C1: placebo daily |
| Waldinger 1998 | I1: fluoxetine 20 mg daily I2: fluvoxamine 100 mg daily I3: paroxetine 20 mg daily I4: sertraline 50 mg daily |
C1: placebo daily |
| Yilmaz 1999 | I1: fluoxetine 20 mg daily | C1: placebo daily |
C: comparator; I: intervention; PDE5: phosphodiesterase‐5.