Comparison 1. SSRI versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Participant perception of change with treatment	6	3260	Risk Ratio (M‐H, Random, 95% CI)	1.92 [1.66, 2.23]
1.2 Participant satisfaction with intercourse	3	4273	Risk Ratio (M‐H, Random, 95% CI)	1.63 [1.42, 1.87]
1.3 Study withdrawal due to adverse events	20	7367	Risk Ratio (M‐H, Random, 95% CI)	3.80 [2.61, 5.51]
1.4 Perceived control over ejaculation	3	4273	Risk Ratio (M‐H, Random, 95% CI)	2.29 [1.72, 3.05]
1.5 Participant distress about PE	1	652	Risk Ratio (M‐H, Random, 95% CI)	1.54 [1.26, 1.88]
1.6 Relationship difficulties	1	652	Risk Ratio (M‐H, Random, 95% CI)	1.20 [1.07, 1.34]
1.7 Adverse events	17	4624	Risk Ratio (M‐H, Random, 95% CI)	1.71 [1.48, 1.99]
1.8 Intravaginal ejaculatory latency time	20	5872	Mean Difference (IV, Random, 95% CI)	3.09 [1.94, 4.25]
1.9 Depression	1	14	Risk Ratio (M‐H, Random, 95% CI)	2.00 [0.23, 17.34]