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. 2021 Mar 21;2021(3):CD012799. doi: 10.1002/14651858.CD012799.pub2

Comparison 3. Subgroup analysis: comparison of long‐acting agents.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
3.1 Participant perception of change with treatment 2 46 Risk Ratio (M‐H, Random, 95% CI) 8.48 [2.21, 32.51]
3.1.1 Citalopram 1 26 Risk Ratio (M‐H, Random, 95% CI) 9.00 [1.32, 61.24]
3.1.2 Duloxetine 1 20 Risk Ratio (M‐H, Random, 95% CI) 8.00 [1.21, 52.69]
3.2 Study withdrawal due to adverse events 14 1315 Risk Ratio (M‐H, Random, 95% CI) 2.00 [0.92, 4.34]
3.2.1 Citalopram 3 164 Risk Ratio (M‐H, Random, 95% CI) 3.00 [0.13, 70.74]
3.2.2 Dapoxetine 2 383 Risk Ratio (M‐H, Random, 95% CI) 7.64 [0.99, 58.71]
3.2.3 Duloxetine 1 20 Risk Ratio (M‐H, Random, 95% CI) Not estimable
3.2.4 Escitalopram 1 276 Risk Ratio (M‐H, Random, 95% CI) 2.00 [0.37, 10.74]
3.2.5 Fluoxetine 3 72 Risk Ratio (M‐H, Random, 95% CI) 2.59 [0.34, 19.59]
3.2.6 Fluvoxamine 1 15 Risk Ratio (M‐H, Random, 95% CI) 1.54 [0.09, 25.86]
3.2.7 Paroxetine 4 281 Risk Ratio (M‐H, Random, 95% CI) 1.76 [0.35, 8.91]
3.2.8 Sertraline 3 104 Risk Ratio (M‐H, Random, 95% CI) 0.43 [0.05, 3.56]
3.3 Adverse events 13 1204 Risk Ratio (M‐H, Random, 95% CI) 2.00 [1.44, 2.78]
3.3.1 Citalopram 2 106 Risk Ratio (M‐H, Random, 95% CI) 3.00 [0.51, 17.57]
3.3.2 Clomipramine 1 42 Risk Ratio (M‐H, Random, 95% CI) 4.40 [1.06, 18.32]
3.3.3 Dapoxetine 2 356 Risk Ratio (M‐H, Random, 95% CI) 2.54 [1.34, 4.81]
3.3.4 Duloxetine 1 20 Risk Ratio (M‐H, Random, 95% CI) 3.00 [0.37, 24.17]
3.3.5 Escitalopram 1 254 Risk Ratio (M‐H, Random, 95% CI) 1.69 [0.69, 4.15]
3.3.6 Fluoxetine 4 140 Risk Ratio (M‐H, Random, 95% CI) 2.50 [1.29, 4.86]
3.3.7 Paroxetine 1 155 Risk Ratio (M‐H, Random, 95% CI) 2.50 [0.91, 6.90]
3.3.8 Sertraline 3 131 Risk Ratio (M‐H, Random, 95% CI) 1.33 [0.74, 2.39]
3.4 Intravaginal ejaculatory latency time 14 576 Mean Difference (IV, Random, 95% CI) 3.36 [1.62, 5.10]
3.4.1 Citalopram 3 157 Mean Difference (IV, Random, 95% CI) 4.85 [3.14, 6.56]
3.4.2 Duloxetine 1 20 Mean Difference (IV, Random, 95% CI) 1.52 [0.80, 2.24]
3.4.3 Fluoxetine 5 149 Mean Difference (IV, Random, 95% CI) 2.46 [1.52, 3.39]
3.4.4 Fluvoxamine 1 12 Mean Difference (IV, Random, 95% CI) 0.59 [‐0.35, 1.53]
3.4.5 Paroxetine 3 107 Mean Difference (IV, Random, 95% CI) 6.51 [0.33, 12.68]
3.4.6 Sertraline 4 131 Mean Difference (IV, Random, 95% CI) 2.55 [1.54, 3.56]
3.5 Depression 1 14 Risk Ratio (M‐H, Random, 95% CI) 2.00 [0.23, 17.34]
3.5.1 Fluoxetine 1 14 Risk Ratio (M‐H, Random, 95% CI) 2.00 [0.23, 17.34]