| 4.1 Participant perception of change with treatment |
4 |
3214 |
Risk Ratio (M‐H, Random, 95% CI) |
1.87 [1.66, 2.10] |
| 4.1.1 Dapoxetine 30 mg daily |
1 |
508 |
Risk Ratio (M‐H, Random, 95% CI) |
1.87 [1.37, 2.54] |
| 4.1.2 Dapoxetine 30 mg on‐demand |
2 |
1021 |
Risk Ratio (M‐H, Random, 95% CI) |
2.00 [1.33, 3.01] |
| 4.1.3 Dapoxetine 60 mg daily |
1 |
500 |
Risk Ratio (M‐H, Random, 95% CI) |
1.68 [1.23, 2.30] |
| 4.1.4 Dapoxetine 60 mg on‐demand |
2 |
1185 |
Risk Ratio (M‐H, Random, 95% CI) |
1.98 [1.58, 2.48] |
| 4.2 Participant satisfaction with intercourse |
3 |
2968 |
Risk Ratio (M‐H, Random, 95% CI) |
1.53 [1.37, 1.71] |
| 4.2.1 Dapoxetine 30 mg daily |
1 |
500 |
Risk Ratio (M‐H, Random, 95% CI) |
1.41 [1.08, 1.85] |
| 4.2.2 Dapoxetine 30 mg on‐demand |
1 |
1309 |
Risk Ratio (M‐H, Random, 95% CI) |
1.59 [1.33, 1.90] |
| 4.2.3 Dapoxetine 60 mg daily |
1 |
507 |
Risk Ratio (M‐H, Random, 95% CI) |
1.39 [1.07, 1.82] |
| 4.2.4 Dapoxetine 60 mg on‐demand |
1 |
652 |
Risk Ratio (M‐H, Random, 95% CI) |
1.61 [1.32, 1.98] |
| 4.3 Study withdrawal due to adverse events |
7 |
6378 |
Risk Ratio (M‐H, Random, 95% CI) |
4.54 [2.89, 7.14] |
| 4.3.1 Dapoxetine 30 mg daily |
1 |
533 |
Risk Ratio (M‐H, Random, 95% CI) |
3.03 [0.37, 25.01] |
| 4.3.2 Dapoxetine 30 mg on‐demand |
3 |
2390 |
Risk Ratio (M‐H, Random, 95% CI) |
2.44 [1.06, 5.59] |
| 4.3.3 Dapoxetine 60 mg daily |
3 |
916 |
Risk Ratio (M‐H, Random, 95% CI) |
8.76 [2.10, 36.49] |
| 4.3.4 Dapoxetine 60 mg on‐demand |
3 |
2539 |
Risk Ratio (M‐H, Random, 95% CI) |
6.51 [3.64, 11.66] |
| 4.4 Perceived control over ejaculation |
3 |
4273 |
Risk Ratio (M‐H, Random, 95% CI) |
2.29 [1.72, 3.05] |
| 4.4.1 Dapoxetine 30 mg daily |
1 |
500 |
Risk Ratio (M‐H, Random, 95% CI) |
1.79 [1.26, 2.53] |
| 4.4.2 Dapoxetine 30 mg on‐demand |
1 |
1305 |
Risk Ratio (M‐H, Random, 95% CI) |
3.70 [2.72, 5.04] |
| 4.4.3 Dapoxetine 60 mg daily |
1 |
507 |
Risk Ratio (M‐H, Random, 95% CI) |
1.78 [1.26, 2.52] |
| 4.4.4 Dapoxetine 60 mg on‐demand |
2 |
1961 |
Risk Ratio (M‐H, Random, 95% CI) |
2.28 [1.65, 3.16] |
| 4.5 Participant distress about PE |
1 |
652 |
Risk Ratio (M‐H, Random, 95% CI) |
1.54 [1.26, 1.88] |
| 4.5.1 Dapoxetine 60 mg on‐demand |
1 |
652 |
Risk Ratio (M‐H, Random, 95% CI) |
1.54 [1.26, 1.88] |
| 4.6 Relationship difficulties |
1 |
652 |
Risk Ratio (M‐H, Random, 95% CI) |
1.20 [1.07, 1.34] |
| 4.6.1 Dapoxetine 60 mg on‐demand |
1 |
652 |
Risk Ratio (M‐H, Random, 95% CI) |
1.20 [1.07, 1.34] |
| 4.7 Adverse events |
6 |
3818 |
Risk Ratio (M‐H, Random, 95% CI) |
1.74 [1.46, 2.07] |
| 4.7.1 Dapoxetine 30 mg daily |
2 |
1028 |
Risk Ratio (M‐H, Random, 95% CI) |
1.64 [1.30, 2.07] |
| 4.7.2 Dapoxetine 30 mg on‐demand |
1 |
581 |
Risk Ratio (M‐H, Random, 95% CI) |
1.47 [1.20, 1.79] |
| 4.7.3 Dapoxetine 60 mg daily |
3 |
891 |
Risk Ratio (M‐H, Random, 95% CI) |
2.73 [2.03, 3.66] |
| 4.7.4 Dapoxetine 60 mg on‐demand |
2 |
1318 |
Risk Ratio (M‐H, Random, 95% CI) |
1.56 [1.23, 1.99] |
| 4.8 Intravaginal ejaculatory latency time |
4 |
5173 |
Mean Difference (IV, Random, 95% CI) |
1.48 [1.20, 1.75] |
| 4.8.1 Dapoxetine 30 mg daily |
1 |
502 |
Mean Difference (IV, Random, 95% CI) |
1.80 [1.27, 2.33] |
| 4.8.2 Dapoxetine 30 mg on‐demand |
3 |
2329 |
Mean Difference (IV, Random, 95% CI) |
1.37 [0.86, 1.89] |
| 4.8.3 Dapoxetine 60 mg daily |
1 |
504 |
Mean Difference (IV, Random, 95% CI) |
1.50 [0.98, 2.02] |
| 4.8.4 Dapoxetine 60 mg on‐demand |
2 |
1838 |
Mean Difference (IV, Random, 95% CI) |
1.53 [1.09, 1.97] |
