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Distribution of HBV DNA 5mC and 5hmC in adult transgenic mouse liver. The CpG DNA methylation (5mC plus 5hmC, bisulfite treatment; 5mC, oxidative bisulfite treatment) frequency distributions across the 11, 38, and 13 sites within HBV nucleotide coordinates 341 to 711, 1215 to 1629, and 2264 to 2474, respectively, for the viral genome from the livers of a male (A to C) and female (D to F) adult HBV transgenic mouse is shown.
